Research Articles on Cannabis and Migraines

Research Articles on Cannabis and Migraines

Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population


No clinical trials are currently available that demonstrate the effects of marijuana on patients with migraine headache; however, the potential effects of cannabinoids on serotonin in the central nervous system indicate that marijuana may be a therapeutic alternative. Thus, the objective of this study was to describe the effects of medical marijuana on the monthly frequency of migraine headache. Medical Cannabis & Migraines

Migraine headaches are so painful that from as far back as the Stone Age, sufferers desperate for relief would submit to trepanation, literally boring or scraping a hole in the skull.

While today’s treatments (typically, administration of a class of medications called triptans) are less radical, the desperation felt by sufferers remains. Those with chronic symptoms—who get migraines 15 or more days a month—show particularly low effectiveness with triptans, and often experience negative side-effects.

Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache


The use of cannabis, or marijuana, for medicinal purposes is deeply rooted though history, dating back to ancient times. It once held a prominent position in the history of medicine, recommended by many eminent physicians for numerous diseases, particularly headache and migraine. Through the decades, this plant has taken a fascinating journey from a legal and frequently prescribed status to illegal, driven by political and social factors rather than by science. However, with an abundance of growing support for its multitude of medicinal uses, the misguided stigma of cannabis is fading, and there has been a dramatic push for legalizing medicinal cannabis and research.

Endocannabinoids and migraine


Experimental evidence demonstrates the antinociceptive action of endocannabinoids (eCBs) and their role in the modulation of trigeminovascular system activation, suggesting that the endocannabinoid system (ECS) may be dysfunctional in migraine, a neurovascular disorder characterized by recurrent episodic headaches.

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