Research Articles on Cannabis and Migraines

Research Articles on Cannabis and Migraines

Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population

https://www.ncbi.nlm.nih.gov/

STUDY OBJECTIVE:

No clinical trials are currently available that demonstrate the effects of marijuana on patients with migraine headache; however, the potential effects of cannabinoids on serotonin in the central nervous system indicate that marijuana may be a therapeutic alternative. Thus, the objective of this study was to describe the effects of medical marijuana on the monthly frequency of migraine headache.

Tilray.ca: Medical Cannabis & Migraines

https://www.tilray.ca/

Migraine headaches are so painful that from as far back as the Stone Age, sufferers desperate for relief would submit to trepanation, literally boring or scraping a hole in the skull.

While today’s treatments (typically, administration of a class of medications called triptans) are less radical, the desperation felt by sufferers remains. Those with chronic symptoms—who get migraines 15 or more days a month—show particularly low effectiveness with triptans, and often experience negative side-effects.

Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache

https://www.ncbi.nlm.nih.gov/

BACKGROUND:

The use of cannabis, or marijuana, for medicinal purposes is deeply rooted though history, dating back to ancient times. It once held a prominent position in the history of medicine, recommended by many eminent physicians for numerous diseases, particularly headache and migraine. Through the decades, this plant has taken a fascinating journey from a legal and frequently prescribed status to illegal, driven by political and social factors rather than by science. However, with an abundance of growing support for its multitude of medicinal uses, the misguided stigma of cannabis is fading, and there has been a dramatic push for legalizing medicinal cannabis and research.

Endocannabinoids and migraine

https://www.researchgate.net/

ABSTRACT:

Experimental evidence demonstrates the antinociceptive action of endocannabinoids (eCBs) and their role in the modulation of trigeminovascular system activation, suggesting that the endocannabinoid system (ECS) may be dysfunctional in migraine, a neurovascular disorder characterized by recurrent episodic headaches.

Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population

STUDY OBJECTIVE:
No clinical trials are currently available that demonstrate the effects of marijuana on patients with migraine headache; however, the potential effects of cannabinoids on serotonin in the central nervous system indicate that marijuana may be a therapeutic alternative. Thus, the objective of this study was to describe the effects of medical marijuana on the monthly frequency of migraine headache.

Osler on Migraine

Did you know that Doctors began treating migraines with cannabis as early as the 1800s?
Sir William Osler is commonly referred to as the “Father of Modern Medicine” and wrote the famous medical textbook called The Principles and Practice of Medicine. He thought cannabis is “the most satisfactory” remedy for migraine. Read more here!

Study: The Use of Cannabis for Headache Disorders

ABSTRACT:
Headache disorders are common, debilitating, and, in many cases, inadequately managed by existing treatments. Although clinical trials of cannabis for neuropathic pain have shown promising results, there has been limited research on its use, specifically for headache disorders. This review considers historical prescription practices, summarizes the existing reports on the use of cannabis for headache, and examines the preclinical literature exploring the role of exogenous and endogenous cannabinoids to alter headache pathophysiology. Currently, there is not enough evidence from well-designed clinical trials to support the use of cannabis for headache, but there are sufficient anecdotal and preliminary results, as well as plausible neurobiological mechanisms, to warrant properly designed clinical trials. Such trials are needed to determine short- and long-term efficacy for specific headache types, compatibility with existing treatments, optimal administration practices, as well as potential risks.

Study: Therapeutic Use of Cannabinoids - Dose Finding, Effects and Pilot Data of Effects in Chronic Migraine and Cluster Headache

A study presented at the Congress of the European Academy of Neurology has confirmed that cannabinoids are suitable for migraine prophylaxis. The study investigated the use of cannabinoids for migraine prevention as well as the treatment of migraine and acute cluster headaches.

New Study Confirms That Cannabis Can Help Migraine Sufferers

Cannabis has long been used for the treatment of migraines, but only in recent years have scientists closed in on the reasons why. A new study published this week from Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of Colorado looked at the effects of inhaled and ingested cannabis in migraine sufferers, and the results confirmed what previous studies had begun to unearth.

Medical Journal: History of non-drug treatment in headache, particularly migraine

Abstract
Although new invasive procedures for the treatment of migraine have evolved during the past decades, the application of invasive procedures for this indication is not new. In this review, the history of non-drug treatments for migraine is discussed. Historical texts by physicians known to have written on headache and migraine (hemicrania), well-known books by physicians from the main historical periods up to 1900 and mainstream 20th century neurology handbooks were analysed. A large number of treatments have been tried, based on contemporaneous pathophysiological models that were not only applied to headache, but to medicine in general…

CrescoLabs Article: A helpful article on Migraines and Cannabis (includes great research links!)

A Brief Description
Marijuana is the best treatment for migraines, writes the father of internal medicine and founder of Johns Hopkins Hospital, Dr. Sir William Osler, in “the Principles and Practice of Medicine” first published in 1892. He writes, “Cannabis indica is probably the most satisfactory remedy [for migraines].”

Not to be confused with a common headache, migraines are a neurological disorder characterized by a collection of symptoms that cause one of the most debilitating conditions suffered by humans. Less oxygen reaches the brain as a result of the restricted blood flow and higher levels of serotonin are produced. Platelets, the blood cells that aid in clotting, become stuck in the blood pathways as vessels outside the brain are contracted. There are two types of migraines: Classic and Common.

Study: Endocannabinoid System and Migraine Pain: An Update

INTRODUCTION
Migraine is one of the most disabling painful conditions and a very common disorder (Global Burden of Disease, 2015). Although the pathophysiology of migraine is still largely elusive, the trigeminovascular system (TS) activation and the neurogenic inflammation of the dura mater are widely recognized as two key mechanisms underlying migraine attacks (Moskowitz, 1993).

Studies Claim Medical Cannabis Effective For Treating Migraines

A study published in the journal, Pharmacotherapy, aims to show that people suffering chronically from headaches could control their condition by using the right type, and amount, of medical cannabis.


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